The Rat Uterus after U-74389G Process

Abstract

Aim: This study co-evaluated the 4 quoted histologic variables after the lazaroid U-74389G (L) drug administration. The calculation was based on the results of 2 preliminary studies, each one evaluating two respective histologic variables of Endometrial Edema (EE) and Uterus Inflammation (UI) or Endometrial Karyorrhexis (EK) and Uterus Congestion (UC); in an induced ischemia reperfusion animal experiment. Materials and methods: The 2 main experimental endpoints at which the EE, UI and EK, UC scores were evaluated was the 60th reperfusion min (for the groups A and C) and the 120th reperfusion min (for the groups B and D). Specially, the groups A and B were processed without drugs, whereas the groups C and D after L administration. Results: The first preliminary study showed that L has a non-significant recessing potency for EE and UI histologic parameters at the “without lesions” grade 0.2636364±0.14594051 (p-values=0.0698). The second preliminary study showed that L has a non-significant recessing potency for EK and UC histologic parameters at the “without lesions” grade 0.1253529 ± 0.08529668 (p-values=0.1373) since they were co-evaluated together. These 2 studies were co-evaluated since they came from the same experimental setting. This study co-evaluated the combined diagnostic values of the four variables together. Conclusion: L administration and reperfusion time together non-significantly accentuated the 4 histologic variables within the “without lesions alterations” score 0.0758471 [-0.1464624 - +0.2981566] (p-value=0.4940).