Abstract
The Raetz Pathway for Lipid A Biosynthesis: Christian Rudolf Hubert Raetz, MD PhD, 1946–2011
Highlights
Chris Raetz (Fig. 1) passed away on August 16, 2011 after a three-year battle with anaplastic thyroid cancer
Chris had a deep mechanistic understanding of chemistry likely instilled by his parents
His training and research interests provided a breadth of knowledge in medicine, pharmacology, biochemistry, genetics, and structural biology, which he applied to a lifetime pursuit of mechanistic understanding of lipid metabolism
Summary
Chris Raetz (Fig. 1) passed away on August 16, 2011 after a three-year battle with anaplastic thyroid cancer. Chris Raetz’s most noted contributions to phospholipid and lipopolysaccharide biochemistry fall into four areas: 1) the development of general methods for the isolation of mutants in phospholipid biosynthesis; 2) the discovery of the enzymatic pathways for the assembly and modification of the Lipid A component of lipopolysaccharide; 3) the discovery of potent new antibiotics that target the Lipid A system; and 4) the elucidation of the high-resolution 3D structures of some of the enzymes of what should be coined the “Raetz Pathway for Lipid A Biosynthesis” [1]. While in Kennedy’s lab as a graduate student, Chris isolated both CDP- and dCDP-diacylglycerol as minor lipids in E. coli extracts [4].
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