Abstract
This study was performed to evaluate the radioprotective and anticancer effect of banana peels extract on male mice. Sixty male mice weighted 18- were used, the animals divided equally into six groups as follow first group act as normal , second group (Tumor control) implanted with Ehrlich tumor, third group ,irradiated group exposed to single dose of 3.0 GY of gamma rays, fourth group (banana peels extract 300 mg/kg/day orally for 3weeks, fifth group (tumor implanted + banana peels extract 300 mg/kg/day orally for 3weeks, sixth group (irradiated with dose 3.0 GY gamma+ 300 mg/kg/day for 3 weeks). At the end of experiment mice were sacrificed by anesthesia and the blood were collected to evaluate biochemical parameters (Complete Blood Count (CBC), Carcino embryonic antigen,(), Malonaldehyde (), Molecular study, electrophoretic assayed. The results showed that banana peels extract ameliorate the alteration in in irradiated and tumor group, and significantly decrease pâ¤0.05 the elevation of Carcino embryonic antigen in tumor implanted group, significantly decrease the elevation of Malonaldehyde in tumor implanted group and irradiated group. According to protein fractions and western blotting data it could be concluded that, addition banana peels extract consider a crucial impact for Irradiation dose which cleared through huge increase of Polymorphism % for addition banana peels extract (20%) comparing with to Irradiation treatment which didnât reflect polymorphism. Furthermore, noticeable stimulation for P53 expression level was detected for applying banana peels extract and Irradiation as Compound dosage.
Highlights
Cancer is a multi-factorial disease in the world and economic burden
According to protein fractions and western blotting data it could be concluded that, addition banana peels extract consider a crucial impact for Irradiation dose which cleared through huge increase of Polymorphism % for addition banana peels extract (20%) comparing with to Irradiation treatment which didn’t reflect polymorphism Table 7
Cancer is an abnormal growth of cells caused by multiple changes in gene expression leading to deregulate balance of cell proliferation and cell death causing significant morbidity [24]
Summary
Cancer is a multi-factorial disease in the world and economic burden. At all ages, cancer may be affect adults and even fetuses, and the hazard for most varieties increases with age [1]. According to World Health Organization, every year more than 10 million new cases of cancer are diagnosed, and in 2020 the statistical tendencies indicate that this number would double [4]. Phenolic compounds derived from natural sources have been found that it possesses antioxidant, anti-inflammatory and has anti-proliferative effects [6]. Banana (Musa species), is one of the important valued plant species which having a number of pharmacological activities [7]. Tocopherol, beta-carotene, phenolic groups, dopamine and gallocatechin had been included in Musa acuminate as antioxidant compounds [9,10]. Flavonoids and phenols in medicinal plants have a positively role in cancer prevenation through the regulation of genetic pathways without any side effects [13,14]. Inhibition of cell proliferation, stimulate of apoptosis, Inhibition of cell invasion and subcellular signaling pathways [15,16]
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