Abstract
PurposeTo evaluate the effects of manganese superoxide dismutase (Mn-SOD) from thermophilic bacterium HB27 (name as Tt-SOD) on chemical cystitis.MethodsControl and experimental rats were infused by intravesical saline or hydrochloric acid (HCl) on the first day of the experiments. Saline, sodium hyaluronate (SH) or Tt-SOD were infused intravesically once a day for three consequent days. On the fifth day, the rats were weighted and sacrificed following a pain threshold test. The bladder was harvested for histological and biochemical analyses.ResultsTt-SOD could reduce the bladder index, infiltration of inflammatory cells in tissues, serum inflammatory factors and SOD levels, mRNA expression of inflammatory factors in tissues, and increase perineal mechanical pain threshold and serum MDA and ROS levels in HCl-induced chemical cystitis. Furthermore, Tt-SOD alleviated inflammation and oxidative stress by the negative regulation of the NF-κB p65 and p38 MAPK signaling pathway.ConclusionsIntravesical instillation of Tt-SOD provides protective effects against HCl-induced cystitis.
Highlights
Chemotherapy is recognized as the most common treatment for patients with bladder cancer, and chemical cystitis is the most common complication following chemotherapy
To assess whether Tt-SOD pretreatment alters the bladder-related pain on hydrochloric acid (HCl)-induced cystitis, we measured the perineal mechanical threshold as a substitute for bladder-related pain
The results indicated that the perineal mechanical threshold in the HCl group was significantly
Summary
Chemotherapy is recognized as the most common treatment for patients with bladder cancer, and chemical cystitis is the most common complication following chemotherapy. International Urology and Nephrology surgical procedures are performed: bladder augmentation or ureteral replantation This caused distress, depression, and in some instances lead to patients refusing further chemotherapy, thereby compromising their treatment plan. Bladder mucosa can prevent circulation of the urine with high permeability solutes as well as pathogen invasion into the urinary tissue and into the blood stream. It can secrete inflammatory mediators, neurotransmitters and can be used as a sensory and external signal to confer tissue protection [2, 3]. It has been reported that a large amount of ROS is produced during cystitis [5]
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