Abstract

AbstractWe studied the protective and curative action of an ethanol extract of Withania frutescens leaves against CCl4‐induced hepatotoxicity. Hepatoprotective activity was evaluated in terms of the LD50 of CCl4, the modification of Nembutal‐induced sleep, the action on bile flow, serum transaminase and hepatic fatty acids levels and a histopathological study of liver tissue. Curative action was assessed by measuring the duration of Nembutal‐induced sleep and with a histopathological study of liver tisue. The findings indicate that the leaf extract has both preventative and curative activity against CCL4‐induced liver damage.

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