Abstract

Even though some reports unveiled that coronavirus 2019 (COVID-19) cases can be manifested as asymptomatic, there is limited information on how much these cases are significant. Understanding the possible proportion of asymptomatic cases among confirmed patients might help in re-considering of who should be tested for the SARS-CoV-2 infection. Therefore, this study was aimed to summarize the proportion of asymptomatic cases among SARS-COV-2 infected people since the outbreak of COVID-19. <i>Methods</i>: Different studies were searched from databases (PubMed, Medline) by using searching terms. Finally, all eligible articles were selected by using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2009 flow diagram. <i>Results</i>: A total of 14 articles that reported asymptomatic cases of COVID-19 were included in this systematic review. The sample size of the studies was ranged from 8 to 2143. Out of the total cases, the overall proportion of asymptomatic cases was 25.9% that ranged from 3.23% to 78%. This systematic review also summarized that there was 17. 6%, 4.8%, and 3.23% to 62.2% of asymptomatic cases among pregnant mothers, children, and the adult general population, respectively. <i>Conclusion and Remarks</i>: This review showed that the proportion of asymptomatic SARS-CoV-2 infected people is high. Hence, to tackle COVID-19, all concerned bodies should strengthen the screening of asymptomatic cases as part of contact tracing efforts.

Highlights

  • Coronaviruses belong to a large family of single-stranded RNA viruses that are causative agents of the common cold and severe respiratory infections, which include Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), [1,2,3,4,5]

  • Zhu et al stated their doubt that there is unclear evidence of whether asymptomatic infection exists for European Journal of Clinical and Biomedical Sciences 2020; 6(5): 84-89

  • Further studies are warranted to generate weight of evidence, with the limited shred of information, there are a significant number of asymptomatic SARS-CoV-2 infected people

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Summary

Introduction

Coronaviruses belong to a large family of single-stranded RNA (ssRNA) viruses that are causative agents of the common cold and severe respiratory infections, which include Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), [1,2,3,4,5]. The infection caused by SARS-CoV-2 was officially designated ‘coronavirus disease 2019’ (COVID-19) by World Health Organization (WHO), [7]. Different reports showed that some of the SARS-CoV-2 infected individuals are asymptomatic, and the potential sources of the infection, different setups are limited to testing individuals based on predetermined conditions such as clinical symptoms and/or exposure history. Zhu et al stated their doubt that there is unclear evidence of whether asymptomatic infection exists for European Journal of Clinical and Biomedical Sciences 2020; 6(5): 84-89

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