Abstract
PurposeIn colorectal cancer (CRC), whether the immune score can be used to predict the clinical prognosis of the patient has not been completely established. Besides, the prognostic values of tumor-infiltrating lymphocytes (TILs) in different anatomical locations, counting sites, and subtypes have been controversial. The purpose of this meta-analysis is to analyze and determine the prognostic value of TILs indices including TIL subsets, infiltrating sites, and anatomical sites.MethodsRelevant literature was obtained by searching PubMed and Google Scholar. The pooled hazard ratio (HR) of the overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS) was computed to investigate the prognostic significance of CD3+, CD8+, CD45RO+, and FOXP3+ T cells.ResultsA total of 22 studies involving 5108 patients were included in the meta-analysis. In CC, based on T cell subtypes analysis, the final results indicated that CD8+ and FOXP3+ infiltrating cells, but not CD3+ T cells were prognostic markers for DFS and OS. In addition, with regard to the counting location of TILs, subgroup analysis revealed that only high FOXP3+ infiltrates in the tumor stroma (ST) were significantly associated with OS (HR = 0.38, 95% confidence interval (CI) = 0.22–0.67, P = 0.0007), whereas in invasive margin (IM), high density of CD3+ infiltrating cells indicated increased DFS (HR = 0.76, 95% CI = 0.62–0.93, P = 0.008). At the tumor center (TC), high CD8+ T cells infiltration was associated with improved DFS (HR = 0.50, 95% CI = 0.38–0.65, P < 0.00001). In RC, whether CSS or OS, high-density TIL was associated with improved prognosis.ConclusionIn a single counting site, high-density TILs reflect favorable prognostic value in CC or RC. For CC, more prospective studies are needed to verify whether different anatomical sites affect the distribution of TILs and thus the prognosis of patients. For RC, further studies should analyze the prognostic value of the immune score.
Highlights
Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract globally
The results showed that blood specimen was a major cause of heterogeneity
The results revealed strong evidence that CD8+, FOXP3+, and CDRO45+ T cell are correlated with increased disease-free survival (DFS)
Summary
Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract globally. The latest report estimated that in all new cases of malignant tumors, the incidence and mortality of CRC accounted for 10.2% and 9.2%, respectively [1]. Zhao et al World Journal of Surgical Oncology (2019) 17:85 prognosis in colorectal cancer [6–9]. The presence of Treg (CD4+CD25+FOXP3+T cells), a subset of CD4+ T cells, appears to cause tumor immunosuppression, especially in most solid tumors [12]. High FOXP3+Treg infiltration indicates unfavorable prognosis [13–18]. FOXP3+ T cells predict a favorable prognosis of colorectal cancer [19–21]. CD45RO+ T cell is a subset of memory T cell, whose gene expression patterns overlap with that of Th1 cells and cytotoxic T cells. High CD45RO+ T cell infiltration is closely related to favorable prognosis [9, 22]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
