Abstract
BackgroundSurvivin has been recently identified as a promising novel therapeutic target and prognostic marker in different types of cancer. Here we conducted a comprehensive meta-analysis to better clarify they the precise prognostic and diagnostic value of survivin in head and neck squamous cell carcinoma (HNSCC).MethodsDatabase of PubMed (Medline), Embase, and Web of Science were systematically searched for related published literature up to September 2020. Pooled hazards ratios (HR) and related 95% confidence intervals (CI) were used to estimate the association of survivin expression and survival outcomes in HNSCC patients.ResultsTwenty eight studies with 4891 patients were finally included in this meta-analysis, the pooled analysis indicated that the survivin expression was significantly correlated with poorer overall survival (OS) (HR, 2.02; 95% CI, 1.65–2.47, P < 0.001), and poorer disease-free survival (DFS)/ disease-specific survival (DSS) (HR = 2.03, 95%CI: 1.64–2.52, P < 0.001; HR = 1.92, 95%CI: 1.41–2.60, P < 0.001, receptively). Similar results were observed in subgroup analysis stratified by different cancer types, such as laryngeal squamous cell carcinoma (LSCC) (HR = 1.35, 95%CI: 1.05–1.74, P < 0.001), oral squamous cell carcinomas (OSCC) (HR = 2.45, 95%CI: 1.89–3.17, P < 0.001), nasopharyngeal carcinoma (NPC) (HR = 2.53, 95%CI: 1.76–3.62, P < 0.001) and HNSCC (HR = 1.52, 95%CI: 1.25–1.86, P < 0.001). Furthermore, ethnicity-stratified analysis indicated that survivin was significantly associated with poorer OS among both Asian and Non- Asian HNSCC patients (HR = 2.16, 95%CI: 1.76–2.66; HR = 1.56, 95%CI: 1.33–1.82, respectively).ConclusionsOur results suggested that survivin is predictors of worse prognosis in HNSCC patients. Hence, survivin is a potential therapeutic target for HNSCC.
Highlights
Head and neck squamous cell carcinoma (HNSCC) is ranking as the sixth most prevalent cancer worldwide [1], they develop from the squamous mucosa of the upper aerodigestive tract, including nasal cavity, nasopharynx, larynx, hypopharynx, oropharynx and so on
Twenty eight studies with 4891 patients were included in this meta-analysis, the pooled analysis indicated that the survivin expression was significantly correlated with poorer overall survival (OS) (HR, 2.02; 95% confidence intervals (CI), 1.65–2.47, P < 0.001), and poorer disease-free survival (DFS)/ disease-specific survival (DSS) (HR = 2.03, 95%CI: 1.64– 2.52, P < 0.001; hazards ratios (HR) = 1.92, 95%CI: 1.41–2.60, P < 0.001, receptively)
Similar results were observed in subgroup analysis stratified by different cancer types, such as laryngeal squamous cell carcinoma (LSCC) (HR = 1.35, 95%CI: 1.05–1.74, P < 0.001), oral squamous cell carcinomas (OSCC) (HR = 2.45, 95%CI: 1.89–3.17, P < 0.001), nasopharyngeal carcinoma (NPC) (HR = 2.53, 95%CI: 1.76–3.62, P < 0.001) and head and neck squamous cell carcinoma (HNSCC) (HR = 1.52, 95%CI: 1.25–1.86, P < 0.001)
Summary
Head and neck squamous cell carcinoma (HNSCC) is ranking as the sixth most prevalent cancer worldwide [1], they develop from the squamous mucosa of the upper aerodigestive tract, including nasal cavity, nasopharynx, larynx, hypopharynx, oropharynx and so on. Zhou et al BMC Cancer (2021) 21:424 is necessary to identify more reliable new prognostic biomarkers and therapeutic targets. Survivin is an anti-apoptotic factor and regulate intrinsic and extrinsic apoptotic pathways by interacting with many factors. It plays key roles in cellular stress response by interfering with autophagy. Different proteins of the autophagic machinery, such as Beclin 1, chemokine ligand 2 and light chain 3 interact with survivin [7, 8]. Survivin has been recently identified as a promising novel therapeutic target and prognostic marker in different types of cancer. We conducted a comprehensive meta-analysis to better clarify they the precise prognostic and diagnostic value of survivin in head and neck squamous cell carcinoma (HNSCC)
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