Abstract
Men who have sex with men (MSM) especially those who are HIV positive are at risk for HPV-associated anal cancer. We systematically reviewed studies with data on the prevalence of vaccine preventable anal HPV among men who have sex with men aged 25 or younger and identified 6 studies. None of these studies were specifically designed to determine the prevalence of HPV in this population. Available data, albeit limited, suggest many young MSM may not already be HPV infected. Further studies using representative sampling focused on teenage MSM are required to confirm this.
Highlights
Genital human papillomavirus (HPV) infection is widespread [1,2,3] and usually asymptomatic [4]
Studies demonstrate that the great majority of adult Men who have sex with men (MSM) are infected with multiple HPV types [7,8,9], with a substantial proportion infected with HPV 16 or 18, which together cause about 80% of anal cancers [10,11,12]
None of the studies sought to determine the prevalence of HPV infection among a representative sample of young MSM [7,16,17,18,19]
Summary
Genital human papillomavirus (HPV) infection is widespread [1,2,3] and usually asymptomatic [4]. HPV types 6 and 11 are the types most commonly associated with anogenital warts [5], while types 16 and 18 are associated with HPV related malignancies including anal and cervical cancer [1,2,3,6]. The prophylactic quadrivalent HPV vaccine is effective in preventing infection with HPV types 6, 11, 16 and 18 and in reducing the incidence of anogenital warts and anal intraepithelial neoplasia in males [14,15]. The extent to which young MSM are already infected with HPV at the age at which targeted vaccination is available is not well documented. We undertook a review of studies examining the prevalence of HPV among MSM aged 25 and younger
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