Abstract
Lymphotoxin (LT) and tumor necrosis factor (TNF) are cytokines that probably play a role in several autoimmune diseases. In this report, we describe the detection, in normal nonimmune serum, of naturally occurring antibodies that bind to recombinant human LT and TNF. The naturally occurring antibodies that bind to LT and TNF could explain why normal immunoglobulin is effective therapy in idiopathic thrombocytopenic purpura and Kawasaki syndrome.
Highlights
Lymphotoxin (LT) and tumor necrosis factor (TNF) are cytokines that probably play a role in several autoimmune diseases
When these sera were tested on cytochrome c (cyt-C), no binding of rabbit immunoglobulin was demonstrated
The finding of naturally occurring antibodies to LT and TNF in normal serum is surprising. The presence of these antibodies in 5 consecutive randomly chosen rabbits and in every normal rabbit serum pool tested suggests that the presence of these antibodies is a general phenomenon occurring in normal rabbits
Summary
Lymphotoxin (LT) and tumor necrosis factor (TNF) are cytokines that probably play a role in several autoimmune diseases. Tumor necrosis factor (TNF) and lymphotoxin (LT) are structurally related cytokines that are linked on chromosome 6 in humans [1,2]. Both of these molecules have a wide range of biologic activities, including necrosis of tumors in vivo [2]. From the Departments of Dermatology and Molecular Biology and Biochemistry, University of California, Irvine; and the Veterans Administration Medical Center, Long Beach. MS: Department of Molecular Biology and Biochemistry, University of California, Irvine; Kristen L. BS: Department of Molecular Biology and Biochemistry, University of California, Irvine; Robert S. PhD: Department of Molecular Biology and Biochemistry, University of California, Irvine.
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