Abstract
Racemic acyclic phosphine oxides were separated into their enantiomers applying classical resolution methods based on complexation with chiral host molecules. The preparation of chloro-3-phospholenium chlorides was elaborated by the reaction of 3-phospholene oxides with oxalyl chloride. The cyclic chlorophosphonium salts were key intermediates, as they could be converted to the corresponding 3-phospholene boranes. Moreover, these reactive intermediates could be reacted with chiral alcohols, which enabled us to develop a dynamic resolution of 3-phospholene oxides based on the formation of covalent diastereomeric intermediates. P-Stereogenic phosphine oxide pre-catalysts showed promising enantioselectivity values in a catalytic Wittig-reaction.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Phosphorus, Sulfur, and Silicon and the Related Elements
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
