Abstract
Aim: Determining the prevalence of metabolic syndrome (MS) in the tested sample of pregnant women in the second and third trimesters of pregnancy, as well as the prognostic significance of MS in assessing the course and outcome of pregnancy. Materials and Methods: Prospective cohort study included 135 pregnant women after 24 0/7 weeks of pregnancy, hospitalized in the period from the January 1st, 2014 until September 30th, 2014. Data analysis included descriptive and analytical methods. Results: After assessment of possible confounding effect of age the authors confirmed that women with MS were 1,685-fold more likely give birth by caesarean section (OR = 1.685, p = 0.048), that it was a statistically significant prognostic factor in the earlier weeks of delivery (p = 0.001), and that it was statistically significant prognostic factor of lower Apgar scores in infants (p = 0.003). Conclusion: The early detection of MS during pregnancy reduces perinatal morbidity and is an important factor for the pregnancy outcome.
Highlights
The term metabolic syndrome (MS) formerly known as syndrome X, was specified and determined in 1970s to describe the association of various risk factors and diabetes
The highest incidence of MS in pregnancy is recorded during the last trimester when there is the highest weight gain of pregnant women (30%), as well as during some pathological conditions, such as gestational diabetes, where the frequency of MS reaches up to 36.4% [2] or gestational hypertension, in which the incidence of MS is around 30% [3]
The authors used the definition of the National Cholesterol Education Program (NCEP) which defines MS in the circumstances when at least three of the five proposed criteria are presented [4]: 1) central obesity, 2) dyslipidemia, 3) dyslipidemia (HDL < 40 mg/ dl or 1.03 mmol/l for men and
Summary
The term metabolic syndrome (MS) formerly known as syndrome X, was specified and determined in 1970s to describe the association of various risk factors and diabetes. The terms of MS, insulin resistance, and syndrome X are used for the precise definition of associated abnormalities which are an increased risk for developing diabetes mellitus type 2 and atherosclerotic cardiovascular disease. Studies of MS in the population of pregnant women are not numerous, but it is known that the incidence of MS in early pregnancy is around 3.3% to 10%, while it increases with increasing of gestational weeks and BMI. The authors used the definition of the NCEP which defines MS in the circumstances when at least three of the five proposed criteria are presented [4]: 1) central obesity (waist circumference ≥ 102 cm in men and ≥ 88 cm in the female population), 2) dyslipidemia (triglycerides ≥ 1.7 mmol/ l and 150 mg/ dl), 3) dyslipidemia (HDL < 40 mg/ dl or 1.03 mmol/l for men and
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