Abstract
Background: The aim of this study was to determine the predictive values of endometrial thickness upon the suppression status of estradiol (E2), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) after gonadotropin-releasing hormone analogue (GnRH-a) administrationMethods: Patients underwent in vitro fertilization-embryo transfer (IVF-ET) using GnRH-a;1.875 g leuprolide acetate depot) in a long protocol. The E2, FSH, LH and endometrial thickness were determined on day 2 or 3 of menstruation. We used E2 ＞55 pg/ml, FSH ＞ 10 pg/ml or LH ＞ 10 pg/ml to define pituitary suppression. The sensitivity, specificity, and positive and negative predictive values of different endometrial thickness in predicting the pituitary down-regulation were comparedResults: An endometrial thickness of 5.5 mm gave the most acceptable values of sensitivity and specificity in predicting the suppression of these hormones. Pituitary suppression was effectivel y achieved using 1.875 g of leuprolide acetate depot. Conclusions: An endometrial thickness of 5.5mm is the best cutoff value in predicting the pituitary suppression after a long protocol of GnRH-a administration. The llse of hormone surveys could be selectively omitted, which would simplify and increase the cost-effectiveness of assisted reproductive technology.
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