Abstract
Bering E. proposed the principle of passive immunization at the end of the 19th century. Today, it is still used to treat tetanus, diphtheria, botulism, rabies and poisonous animal bites (snakes, spiders and scorpions). As before, equine antibodies or their fragments are used as an antidote. But the unique properties of antibodies from the yolks of chicken eggs (IgY) make it possible to use them for a wide range of therapeutic and prophylactic purposes. IgY-antibodies are used in several countries (Canada, Germany, Japan, China) on an industrial scale to produce medical and veterinary drugs to protect humans and animals against pathogens, providing highly effective immunological protection. The Romanian Romvac Company SA is a separate company in the series of manufacturers of these drugs. This company produces IgY preparations in limited batches against many antigens and practices the production of personalized antibodies directed at pathogens of a particular patient. This approach is guaranteed to damage the pathogen, however unique it may be. The authors have analyzed many review articles on the use of IgY-technology. These antibodies are nonaddictive, non-toxic, do not interact with rheumatoid factor, complement, or Fc-fragments of immunocompetent cells, and do not cause antibody-dependent reinforcement of infection. Oral administration of specific IgY-antibodies significantly reduces the manifestations of celiac disease and pathological conditions caused by activation of pathogens in the gastrointestinal tract. Passive immunization of young farm animals with IgY-antibodies is economical and practical against many mammals, birds and aquatic animals. The great potential of this new direction can provide a rapid and cost-effective breakthrough in improving the adequate food security of the Russian Federation.
Highlights
Достижения ветеринарной науки и практики have analyzed many review articles on the use of immunoglobulin Y (IgY)-technology
Oral administration of specific IgY-antibodies significantly reduces the manifestations of celiac disease and pathological conditions caused by activation of pathogens in the gastrointestinal tract
Effect of Anti-Helicobacter pylori Urease Antibody (IgY) as a Food Ingredient on the Decrease of H. pylori in the Stomach of Humans Infected with H. pylori // Taiwanese Journal of Agricultural Chemistry and Food Science. – 2003. – Vol 41. – P. 408-414
Summary
Достижения ветеринарной науки и практики have analyzed many review articles on the use of IgY-technology. В экспериментах in vitro было показано, что в искусственной желудочной жидкости активность IgY антител остаётся высокой (82,4 %) даже через 2 ч инкубации при 37 °С. IgY-антитела могут быть использованы при лечении пациентов, страдающих целиакией, и в качестве профилактической меры защиты от непреднамеренного употребления глютена с пищей. Из яиц этих птиц были получены IgY-антитела против H. pylori с хорошими нейтрализующими титрами.
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