Abstract
Fibrogenesis is a frequent pathogenesis in the processes of many diseases from the initial-stage to the end-stage. Unfortunately, mechanisms of fibrogenesis are complex and not fully understood by now. Recently, researches have proved that oxidative stress participates in the process of fibrosis. Some studies suggest that PTEN, a tumor suppressor, is down-regulated in fibrosis, and it will be a new agent for fighting against fibrogenesis. DJ-1, an oncogene product, has been identified as a protein with various functions in cellular transformation, oxidative stress response and transcriptional regulation, and it is considered as a negative regulator of PTEN in tumor. DJ-1 is also observed overexpression in hepatic fibrosis, but the specific effects of it are obscure. We hypothesize that DJ-1 is a double-edged sword in fibrogenesis: DJ-1 may hamper oxidative damage; overexpression of DJ-1 possibly promote fibrogenesis through depressing the expression of PTEN and activating PI3K/Akt pathway subsequently.
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