Abstract
The growing number of female reproductive system disorders creates a need for novel treatment methods. Tissue engineering brings hope for patients, which enables damaged tissue reconstruction. For this purpose, epithelial cells are cultured on three-dimensional scaffolds. One of the most promising materials is chitosan, which is known for its biocompatibility and biodegradability. The aim of the following study was to verify the potential of chitosan-based biomaterials for pelvic organ prolapse regeneration. The scaffolds were obtained under microwave-assisted conditions in crosslinking reactions, using dicarboxylic acids and aminoacid as crosslinkers, including l-glutamic acid, adipic acid, malonic acid, and levulinic acid. The products were characterized over their physicochemical and biological properties. FT–IR analysis confirmed formation of amide bonds. The scaffolds had a highly porous structure, which was confirmed by SEM analysis. Their porosity was above 90%. The biomaterials had excellent swelling abilities and very good antioxidant properties. The cytotoxicity study was performed on vaginal epithelial VK2/E6E7 and human colon cancer HCT116 cell lines. The results showed that after certain modifications, the proposed scaffolds could be used in pelvic organ prolapse (POP) treatment.
Highlights
Disorders of the female reproductive system affect women during their perimenopausal years, and during their childbearing age
FT–IR spectra of all aerogels still showed bands coming from aminoof groups of various intensity, which suggested that biomaterials are capable of
There were glycosidic four different samples to rings the study, which varied by confirmed their chemical aliphatic groups, bonds, as wellsubjected as pyranose were still present, which that composition
Summary
Disorders of the female reproductive system affect women during their perimenopausal years, and during their childbearing age. Depending on the procedure and treatment, there might be physical changes to the urogenital organs, both internally and externally. These changes can have a severe impact on the genitourinary tract, including sexual dysfunction. Available therapies, such as laser treatments or administration of hyaluronic acid or serum, are neither sustainable nor supported by clinical research. There is a great need in designing a new material that is safe but that can provide structural corrections, while maintaining optimal vulvo-vaginal aesthetics and allowing for a pain-free intercourse [1,2,3,4].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
