Abstract
Aims. MAGIC chemotherapy has become the standard of treatment for patients undergoing curative resection for gastric and gastrooesophageal junction (GOJ) cancers. The importance of postoperative component of this regimen is uncertain. The aim of this study was to compare survival and cancer recurrence in patients who have received neoadjuvant and adjuvant chemotherapies according to MAGIC protocol with those patients completing only neoadjuvant chemotherapy. Methods. 66 patients with gastric and GOJ adenocarcinomas treated with neoadjuvant and adjuvant chemotherapies according to the MAGIC protocol were studied. All patients underwent potentially curative surgical resection. The histological, demographic, and survival data were collected for all patients. Results. The median number of neoadjuvant chemotherapy cycles received was 2 (range 1–3). Thirty-one (47%) patients underwent adjuvant chemotherapy with a median of 2 cycles (range 1–3). Patients who have completed both cycles of chemotherapy had significantly improved survival (P = 0.04). Patients with involved lymph nodes and positive longitudinal resection margins had increased incidence of recurrence (P = 0.02) and poor five-year survival (P = 0.03). Conclusions. Patients who received both neoadjuvant and adjuvant chemotherapies for gastric and gastro-oesophageal junction tumours have improved outcomes compared to patients who only received neoadjuvant chemotherapy.
Highlights
The annual worldwide incidence of gastric cancer is approximately one million and is ranked the fourth most common cancer worldwide [1]
In the last two decades, more gastric cancer has been diagnosed in the proximal stomach and around the gastrooesophageal junction (GOJ) [3]
A total of 272 patients underwent surgical resection for gastric (n = 115) and GOJ (n = 157) ACC between 1996 and 2010 at the University Hospital of South Manchester. 66 of these patients received neoadjuvant chemotherapy for gastric and GOJ ACC according to MAGIC chemotherapy protocol and subsequently underwent surgical resection
Summary
The annual worldwide incidence of gastric cancer is approximately one million and is ranked the fourth most common cancer worldwide [1]. In the last two decades, more gastric cancer has been diagnosed in the proximal stomach and around the gastrooesophageal junction (GOJ) [3]. Increased levels of gastrooesophageal reflux disease [4] and obesity [5] are identified as probable causative factors. Both gastric and gastrooesophageal junction (GOJ) cancers are associated with poor five-year survival rates [6,7,8]. Curative treatments involve surgical resection and both neoadjuvant and adjuvant chemotherapies, sometimes combined with radiotherapy [9]. Several trials have used a combination of neoadjuvant and adjuvant chemoradiotherapies to improve outcome with varied success
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
