Amino Acids

The post-translational modification of Fascin: impact on cell biology and its associations with inhibiting tumor metastasis

Publication Date Aug 8, 2022


The post-translational modifications (PTMs), which are crucial in the regulation of protein functions, have great potential as biomarkers of cancer status. Fascin (Fascin actin-bundling protein 1, FSCN1), a key protein in the formation of filopodia that is structurally based on actin filaments (F-actin), is significantly associated with tumor invasion and metastasis. Studies have revealed various regulatory mechanisms of human Fascin, including PTMs. Although a number of Fascin PTM sites have been identified, their exact functions and clinical significance are much less explored. This review explores studies on the functions of Fascin and briefly discusses the regulatory mechanisms of Fascin. Next, to review the role of Fascin PTMs in cell biology and their associations with metastatic disease, we discuss the advances in the characterization of Fascin PTMs, including phosphorylation, ubiquitination, sumoylation, and acetylation, and the main regulatory mechanisms are discussed. Fascin PTMs may be potential targets for therapy for metastatic disease.


Fascin Actin-bundling Protein Main Regulatory Mechanisms Functions Of Fascin Regulation Of Protein Functions Formation Of Filopodia Inhibiting Tumor Metastasis Cell Biology Post-translational Modifications Characterization Of Post-translational Modifications Exact Functions

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