Abstract
COVID-19 infection is a significant and poorly understood problem of modern world medicine. As the virus spreads, data on the clinical picture of the disease and damage to the nervous system are accumulating. Symptoms such as fatigue, anxiety, depression, sleep disturbances and many other neurological and somatic symptoms are often recorded, persist for a long time even after the acute infectious stage of the disease has been stopped, and make it difficult for the patient to fully recover. These symptoms occur even with a mild disease and persist for many months. One of the most common and disabling symptoms of post-COVID syndrome is cognitive impairment, in the formation of which, in addition to the direct ability of the virus to penetrate the nervous system and pathology of the microvasculature, various pathological mechanisms are involved, including dysregulation of cholinergic transmission. A comprehensive approach is important in the treatment of cognitive impairment; it is advisable to use both medication and non-medication methods. The main approaches to the treatment of secondary cognitive disorders are based on the hypothesis of replenishing the defect in mediator systems, including those associated with the death of cholinergic neurons. With these abnormalities, it is advisable to replenish acetylcholine. Among the precursors of choline, choline alfoscerate occupies a special place due to its proven efficacy in the treatment of neurodegenerative diseases, as well as due to data on its multifactorial action. The article presents the actual literature data on the mechanisms of development and features of the clinical manifestations of post-COVID cognitive impairment, as well as materials of experimental and clinical studies of the drug choline alfoscerate (Gliatilin).
Highlights
The main approaches to the treatment of secondary cognitive disorders are based on the hypothesis of replenishing the defect in mediator systems, including those associated with the death of cholinergic neurons
Сведения об авторах: Захаров Денис Валерьевич — д.м.н., врач-невролог, заведующий отделением интегративной терапии больных нейропсихиатрического профиля ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им
Summary
Обозрение психиатрии и медицинской психологии им. В.М. Бехтерева, 2021, Т. 57, No 4, с. 97-105, http//doi.org/10.31363/2313-7053-2021-57-4-97-105 V.M. Bekhterev review of psychiatry and medical psychology, 2021, Т. 57, no 4, pp. 97-105, http//doi.org/10.31363/2313-7053-2021-57-4-97-105 Постковидные когнитивные расстройства. Современный взгляд на проблему, патогенез и терапию Как цитировать: Захаров Д.В., Буряк Ю.В. Постковидные когнитивные расстройства. Современный взгляд на проблему, патогенез и терапию. Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева. 2021; 57:4:97-105. http//doi.org/10.31363/2313-7053-2021-4-97-105
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