The possible protective role of curcumin versus garlic in amiodarone-induced keratopathy in rats

Abstract

Introduction Diabetes is a common serious metabolic disorder, and it may cause nephropathy. Garlic was experimentally documented to have an antidiabetic potential. Aim of the work Investigate the possible protective role of garlic in the structural changes of the renal cortex in diabetic male albino rats. Materials and methods Rats were divided into two main groups; group I included rats that were divided equally into a control group Ia (rats were administered distilled water) and a garlic group Ib (rats were administered 100▒mg/kg garlic powder). Group II (diabetic group) included rats in which diabetes was induced by a single intraperitoneal injection of 60▒mg/kg body weight streptozotocin; then, the rats were divided into two groups: an untreated diabetic group IIa (rats were administered distilled water) and a garlic-treated diabetic group IIb (rats were administered 100▒mg/kg garlic powder). Results At the end of the experiment, the rats in the untreated diabetic group showed a nonsignificant change in their body weight and a significant increase in the mean fasting blood glucose by 40.6%. Microscopic examination of the renal cortex showed structural changes in both the proximal convoluted tubules and distal convoluted tubules in the form of a luminal cast, less basal infolding, and fewer basal mitochondria with loss of its cristae. Loss of microvilli of proximal convoluted tubules, extravasation of red blood cells, and a significant increase in the thickness of the glomerular basement membrane were also observed. However, at the end of the experiment, the garlic-treated diabetic group showed a significant increase in body weight by 21.7%, a significant decrease in the mean fasting blood glucose level by 29.6%, and absence of the most of the structural changes of the renal cortex. Conclusion Garlic could protect against diabetes-induced structural changes in the renal cortex.