Abstract
The following article comprises a summary of various of our observations previously published or reported before the Asociacion Medica Argentina (May 3, 1915) and abstracted in La Prensa Medica (1915, p. 451). A concluding report of the entire investigation is shortly to appear. Different immediate effects occur when pituitary extracts are administered to dogs intravenuously. The chemical composition of the gland is very constant, as are the physiological effects of the gland extracts, but these effects vary qualitatively according to the methods of preparation. Extracts of the fresh glands produce brief vasodepression followed by augmented arterial pressure; during the depressor phase of the reaction the kidney volume is diminished and oliguria occurs, but when the pressure rises a renodilation accompanied by more or less marked diuresis is noted. Sometimes we have noted an initial renocontraction with or without general hypotension which persists for a short time into the hypertensive phase; this may or...
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