Abstract
Activity related to flea-bite hypersensitivity could be recovered from skin fractions of guinea pigs following flea bites. The activity resided in nonsaline-extractable as well as in saline-extractable portions. The former could induce flea-bite hypersensitivity; the latter could induce sensitivity only with adjuvants. The adsorption of materials secreted by the flea to elements of the host's skin, and the role of the host's skin in the induction of flea-bite hypersensitivity is demonstrated.
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