Abstract
Fostered by the success of photodynamic therapy (PDT), light activation of transition metal complexes has raised notable interest for applications in biology and in medicine. The rich photochemistry of metal complexes and the arsenal of chemical reactions accessible via light excitation have been exploited for developing therapeutic agents which exert their biological action through novel mechanisms. This chapter aims to provide an overview of the concepts and strategies adopted by leading scientists in the design and development of photoactivatable metal complexes with potential use in cancer therapy. In particular, we focus on the anticancer properties of Pt, Rh, and Ru complexes which have been demonstrated to be amongst the most promising classes of compounds.
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