Abstract
The pharmacology of the prostaglandins (PGs) and thromboxanes (Txs) released from immunologically challenged guinea-pig lungs is related to their roles in the anaphylactic response. 6-oxo-PGF 1α probably contributes substantially to bronchoconstriction during anaphylaxis. TxB 2 may contribute to the anaphylactic response by increasing SRS-A release and by stimulating leucotaxis. The 15-oxo metabolites of PGE 2 and PGF 2α are rather weak spasmogens, but might modify respiratory muscle contractions and pulmonary vascular resistance. The 15-oxo 13,14 dihydro metabolites of PGE 2, PGF 2α and TxB 2 were inactive in the systems studied, suggesting an important inactivating role for the 13:14 reductase enzyme.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
