Abstract
The periodic stripes and spots that often adorn animals' coats have been largely viewed as self-organizing patterns, forming through dynamics such as Turing's reaction-diffusion within the developing skin. Whether preexisting positional information also contributes to the periodicity and orientation of these patterns has, however, remained unclear. We used natural variation in colored stripes of juvenile galliform birds to show that stripes form in a two-step process. Autonomous signaling from the somite sets stripe position by forming a composite prepattern marked by the expression profile of agouti Subsequently, agouti regulates stripe width through dose-dependent control of local pigment production. These results reveal that early developmental landmarks can shape periodic patterns upstream of late local dynamics, and thus constrain their evolution.
Highlights
Cite this article: Greene NDE, Copp AJ, Andoniadou CL (2019)
Abstracts of papers presented at the 29th Genetic Society’s Mammalian Genetics and Development Workshop held at the UCL Great Ormond Street Institute of Child Health, University College London on Thursday 29th November 2018
The Amyloid Precursor Protein (APP) gene is present on chromosome 21, but other genes are likely to have a role in Alzheimer disease (AD) in Down syndrome (DS) (AD-DS)
Summary
Calderon, Felix D Weiss, Thomas Carroll, Elaine E. A universal yet unexplained feature of CdLS is cognitive impairment. It is not known whether neuronal dysfunction arises primarily from developmental defects in neuronal progenitors, or from an ongoing requirement for cohesin in post-mitotic neurons. To address these questions, we investigated the impact on neuronal gene expression of depleting cohesin at distinct points in development - in the germline, in immature post-mitotic neurons, or in mature neurons. Neuronal genes with key roles in synaptic transmission, connectivity, neuronal development and signaling were selectively downregulated, regardless of whether cohesin function was compromised throughout development, during the differentiation of immature post-mitotic neurons, or in mature neurons for just 24 hours.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
