Abstract
Four chinchillas were exposed for 9, 14, or 18 days to a 0.5-kHz octave band of noise at 95 dB SPL and allowed to recover for 1, 7, 14, or 28 days prior to acute electrophysiological recording. Single-unit data indicated that the pattern of threshold shift closely matched the pattern of hair-cell loss. A 22-dB PTS was associated with a 35% OHC loss in the apex. Lesions of the basal organ of Corti were identified by loss of responsive units, and areas of large OHC loss revealed units with up to 50 dB PTS. In all animals, a “notch” in the distribution of thresholds occurred in the region of 4 kHz. FTC's of units with CF's above the notch were usually normal and their tails are believed responsible for the failure of behavioral measurements to detect their presence or correctly estimate the magnitude of PTS and cochlear damage [W. W. Clark and B. A. Bohne, ARO paper (1977)]. Recovery was complete or nearly so after 36 h for 9-day exposures, and within 48 h for 18-day exposures. The pattern of cochlear damage was consistent with earlier reports [M. P. Fried, et al., Trans. Am. Acad. Ophthal. Otolaryngol. 82, 285–298 (1976); B. A. Bohne, Ann. Otol. Rhinol. Laryngol. 85, 711–724 (1976)]. [Supported by NS 03856].
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