Abstract
BackgroundResearch on quality of life (QOL) with Parkinson’s disease (PD) has examined direct influencing factors, not mediators. The study aim was to explore whether PD severity and poor cognitive function may decrease physical and mental QOL by reducing activities of daily living (ADL) and increasing depression in sequence.MethodsWe conducted a cross-sectional questionnaire study of 150 PD hospital patients in China. PD severity, cognitive function, ADL, depression, and QOL were evaluated. We used structural equation modeling to analyze the mediating effects of ADL and depression on the association between PD severity/cognition and the physical health and mental health component summary scores measured by the SF36 quality of life instrument.ResultsThere was a significant mediating effect of PD severity on physical health via ADL and depression (95% CI: − 0.669, − 0.026), and a significant direct effect (p < 0.001). The mediating effect of PD severity on mental health via ADL and depression was significant (95% CI: − 2.135, − 0.726), but there was no direct effect (p = 0.548). There was a significant mediating effect of cognitive function on physical health via ADL and depression (95% CI: 0.025, 0.219) and a significant direct effect (p < 0.001). The mediating effect of cognitive function on mental health via ADL and depression was significant (95% CI: 0.256, 0.645), but there was no direct effect (p = 0.313). The physical health models showed a partial mediation, and the mental health models showed a complete mediation, of ADL and depression.ConclusionsPD severity and cognitive function increase depression by reducing ADL, leading to lower QOL, and directly or indirectly affect physical health and mental health through different pathways.
Highlights
Parkinson’s disease (PD) is a chronic progressive neurodegenerative disorder that affects middle-aged and older people [1]
There were no differences in mental component summary (MCS) score according to lifestyle factors, but there were significant differences in physical component summary (PCS) score according to age, marital status, and educational backgrounds
PD severity and depression were negatively correlated with PCS and MCS (r = − 0.583 and r = − 0.420)
Summary
Parkinson’s disease (PD) is a chronic progressive neurodegenerative disorder that affects middle-aged and older people [1]. Non-motor PD symptoms, such as cognitive impairment and depression, have attracted increasing attention and may exacerbate disability, affect quality of life (QOL), and shorten life expectancy [2]. The American economist Galbraith first proposed the concept of QOL in 1958 and it has been widely used. He et al Health Qual Life Outcomes (2021) 19:92 as a sociological indicator [3]. The incidence of cognitive impairment gradually increases and eventually develops into Parkinsonism dementia [6]. The pathogenesis of PD and its related complications, such as depression and cognitive impairment, currently remain unclear. The study aim was to explore whether PD severity and poor cognitive function may decrease physical and mental QOL by reducing activities of daily living (ADL) and increasing depression in sequence
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
