Acta Naturae | VOL. 13
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The p53 Protein Family in the Response of Tumor Cells to Ionizing Radiation: Problem Development

Publication Date Nov 15, 2021

Abstract

Survival mechanisms are activated in tumor cells in response to therapeutic ionizing radiation. This reduces a treatments effectiveness. The p53, p63, and p73 proteins belonging to the family of proteins that regulate the numerous pathways of intracellular signal transduction play a key role in the development of radioresistance. This review analyzes the p53-dependent and p53-independent mechanisms involved in overcoming the resistance of tumor cells to radiation exposure.

Concepts

Pathways Of Intracellular Signal Transduction Development Of Radioresistance P53 Protein Family Survival Mechanisms P53 Protein P53-dependent Mechanisms Pathways Of Signal Transduction Resistance Of Cells Tumor Cells Response Of Cells

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