Abstract

Survival mechanisms are activated in tumor cells in response to therapeutic ionizing radiation. This reduces a treatments effectiveness. The p53, p63, and p73 proteins belonging to the family of proteins that regulate the numerous pathways of intracellular signal transduction play a key role in the development of radioresistance. This review analyzes the p53-dependent and p53-independent mechanisms involved in overcoming the resistance of tumor cells to radiation exposure.

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Topics from this Paper

  • Pathways Of Intracellular Signal Transduction
  • Development Of Radioresistance
  • P53 Protein Family
  • Survival Mechanisms
  • P53 Protein
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