Abstract
The incorporation of succinate-1,4-C 14 into the respiratory CO 2 under conditions which are presumed to reflect oxalacetate decarboxylation was stimulated by the addition of glucose or by lowering the pH. The stimulation by glucose disappeared in the presence of bicarbonate, Tris, or strongly buffered phosphate, in agreement with the idea that the stimulatory effect of glucose is principally related to its effect in lowering the pH. The respiration of ascites tumor cells was found to be markedly depressed by inhibitors of DPN-cytochrome c reductase, such as progesterone or amytal, but the addition of succinate restored respiration. This respiration, presumably succinoxidase, was diminished by a decrease in pH. Thus, it is concluded that the over-all effect of pH on succinate oxidation depends on ( a) the activity of succinoxidase which is decreased by lowering the pH, and ( b) the decarboxylation process which increases as the pH is lowered.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
