The Overview of Retrosynthetic Analysis: Guidelines and Approaches

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Retrosynthetic analysis has, in recent years, become increasingly important, especially in designing total synthetic routes. Since retrosynthetic analysis was proposed, there are many substances whose synthetic routes have been deduced or further optimized, which greatly facilitated organic synthesis. Therefore, in order to further the study of organic synthesis, this paper will commence from the background of retrosynthetic analysis and relevant specific concepts to help novices have a preliminary understanding of retrosynthesis. Furthermore, this paper also illustrates some useful approaches of retrosynthetic analysis and some simple examples are used to better the understanding of retrosynthetic analysis, enabling novices to initially establish a basic knowledge system of retrosynthetic analysis.