The orthotropic viscoelastic behavior of aortic elastin

Abstract

In this paper, we studied the viscoelastic behaviors of isolated aortic elastin using combined modeling and experimental approaches. Biaxial stress relaxation and creep experiments were performed to study the time-dependent behavior of elastin. Experimental results reveal that stress relaxation preconditioning is necessary in order to obtain repeatable stress relaxation responses. Elastin exhibits less stress relaxation than intact or decellularized aorta. The rate of stress relaxation of intact and decellularized aorta is linearly dependent on the initial stress levels. The rate of stress relaxation for elastin increases linearly at stress levels below about 60kPa; however, the rate changes very slightly at higher initial stress levels. Experimental results also show that creep response is negligible for elastin, and the intact or decellularized aorta. A quasi-linear viscoelasticity model was incorporated into a statistical mechanics based eight-chain microstructural model at the fiber level to simulate the orthotropic viscoelastic behavior of elastin. A user material subroutine was developed for finite element analysis. Results demonstrate that this model is suitable to capture both the orthotropic hyperelasticity and viscoelasticity of elastin.