Abstract
Oral delivery and retention of zinc and triclosan were measured in man after use of an anti-plaque dentifrice containing these antibacterial agents. Triclosan (25% of the dose) and zinc (24%) were retained in the mouth immediately after toothbrushing and a single mouthrinse. Salivary concentrations fell from 7.5 micrograms g-1 (triclosan) and 7.0 micrograms g-1 (zinc) after 5 min to 0.5 micrograms g-1 (triclosan) and 1.2 micrograms g-1 (zinc), 2 h after brushing.
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