Abstract
The immunological response was studied in the adult hibernating squirrel (Citellus lateralis) infected with coxsackievirus B-3. The complement activity was considerably reduced between the 4th and 9th day of infection, but was restored to the normal level by the 11th day. The neutralizing antibody was first detected in the blood on the fourth day, reached an average ND50 of 10−2.62 on the seventh day after inoculation, and remained at this level.Gamma globulin was demonstrated in the infected olfactory bulb by the direct fluorescent antibody method on the seventh day after inoculation. The specific fluorescence appeared as a surface staining of the infected granule cells, cellule nervose piccole, and within numerous inflammatory cells. On staining with methyl green – pyronin these cells resembled the antibody-producing cells in the spleen.A sequential correlation existed between the development and appearance of the gamma-globulin-producing cells in the spleen and the olfactory bulb which indicated that the lymphoid cells infiltrated into and contributed to the tissue destruction in the olfactory bulb of the infected squirrel.
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