Abstract
BackgroundProgressive supranuclear palsy (PSP) and parkinsonian variant of multiple system atrophy (MSA-P) are clinically difficult to differentiate from idiopathic Parkinson's disease (PD), particularly in the early stages of the disease. Previous reports indicated that the olfactory function is relatively intact or slightly reduced in patients with PSP and MSA-P, suggesting that the odor stick identification test for Japanese (OSIT-J), which is a short and simple noninvasive test that is potentially useful clinically for detecting early-stage PD in Japan, may be useful in the differential diagnosis of early-stage PD from MSA-P and PSP. There is no information on the sensitivity and specificity of OSIT-J in the diagnosis of parkinsonian syndromes such as PSP and MSA-P.MethodsWe assessed the olfactory function using the OSIT-J test in 94 Japanese patients with idiopathic PD, 15 with MSA-P, 7 with PSP, and 29 age-matched control subjects.ResultsThe mean ± SD score of OSIT-J in patients with PD (4.4 ± 2.9) was significantly lower than in patients with MSA-P (8.7 ± 2.2, P < 0.0001), PSP (7.6 ± 2.2, P < 0.0057), and control subjects (10.5 ± 1.3, P < 0.0001). The area under the curve (AUC) of receiver operating characteristic (ROC) to discriminate PD from normal control using OSIT-J scores was 0.97 (95% confidence interval, 0.95-1.00), from MSA-P 0.87 (0.80-0.95), and from PSP 0.81 (0.66-0.96).ConclusionThe OSIT-J is a potentially useful clinical test not only for detection of olfactory deficit in PD but also for differentiating PD from MSA-P and PSP.
Highlights
Progressive supranuclear palsy (PSP) and parkinsonian variant of multiple system atrophy (MSA-P) are clinically difficult to differentiate from idiopathic Parkinson’s disease (PD), in the early stages of the disease
Previous reports indicated that the olfactory function is relatively intact or slightly reduced in patients with PSP and MSA-P [11,12,13,14,15], suggesting that odor stick identification test for Japanese (OSIT-J) may be useful in the differential diagnosis of early-stage PD from MSA-P and PSP [15,16]
The disease duration was longer in PD than in MSA-P and PSP, whereas the HY stage was lower in PD than in MSA-P and PSP (Table 1)
Summary
Progressive supranuclear palsy (PSP) and parkinsonian variant of multiple system atrophy (MSA-P) are clinically difficult to differentiate from idiopathic Parkinson’s disease (PD), in the early stages of the disease. Progressive supranuclear palsy (PSP) and parkinsonian variant of multiple system atrophy (MSA-P) are neurodegenerative disorders that are clinically difficult to differentiate from idiopathic PD, in the early stages of the disease, when the typical clinical signs are not clearly evident [10]. Previous reports indicated that the olfactory function is relatively intact or slightly reduced in patients with PSP and MSA-P [11,12,13,14,15], suggesting that OSIT-J may be useful in the differential diagnosis of early-stage PD from MSA-P and PSP [15,16]. The aim of the present study was to evaluate the OSIT-J in patients with idiopathic PD, MSA-P, and PSP
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
