Abstract
The National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program (SRP) funds a wide range of university-based research to address public health concerns arising from hazardous substances in the environment. Since its inception in 1987, the SRP has applied a multidisciplinary approach that combines laboratory-based and population-based studies, as well as community engagement and research translation, to improve our understanding of and minimize the health effects associated with exposures to contaminants. For example, SRP-funded researchers are investigating (1) associations between phthalates and preterm birth, (2) prenatal and early-life exposure to chlorinated compounds and adverse neurological effects in later childhood and adulthood, (3) the links between arsenic in drinking water and various cancers, birth outcomes, and adverse effects on intelligence and motor function in children, and (4) associations between metal mixtures and neurodevelopment. Innovative research from SRP-funded investigators is also addressing challenges in environmental epidemiology through the validation of relevant biomarkers and development of immunoassay-based and field-deployable exposure assessment devices. Moving forward, SRP-funded researchers are focusing on the health effects of complex chemical mixtures, determining relevant chemical exposures, identifying developmental windows of susceptibility, analyzing patterns in epidemiologic and toxicologic data to assess risks to human health presented by hazardous substances, and development of tools to facilitate assessment of exposure and toxicity. This presentation will summarize results from SRP epidemiological studies that have linked hazardous substances to health effects, the impact that these studies have had in human health risk assessment, as well as future projects that will address research priority areas in environmental epidemiology.
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