The multiple parameter hemodynamic imaging system based on ARM

Abstract

Optical imaging with high resolution is significant to reveal the functional activities of brain and the mechanism of disease, and has grown into a diverse field. The high-resolution multi-parameters optical imaging system which combines the laser speckle contrast imaging method and optical intrinsic signal imaging method can obtain more hemodynamic information in cortex simultaneously. However, most of current optical imaging systems use He-Ne laser and mercury xenon arc lamp as the light source. Meanwhile, the control unit of the system which includes a personal computer, is not portable. In this paper, we develop a multiple parameters hemodynamic imaging system based on ARM. To make the system more compact, three wavelengths light-emitting diode and laser diode as imaging illuminants were adopted. In addition, the real-time embedded operation system (μC/OS-II) and embedded Graphic User Interface (μC/GUI) were introduced. Animal experimental results also show that changes in oxyhemoglobin, deoxyhemoglobin, total hemoglobin concentration and cerebral blood flow during Cortical Spreading Depression can be simultaneously accessed using this optical imaging system based on embedded ARM.