Abstract
CD36 is a multiligand receptor contributing to glucose and lipid metabolism, immune response, inflammation, thrombosis, and fibrosis. A wide range of tissue expression includes cells sensitive to metabolic abnormalities associated with metabolic syndrome and diabetes mellitus (DM), such as monocytes and macrophages, epithelial cells, adipocytes, hepatocytes, skeletal and cardiac myocytes, pancreatic β-cells, kidney glomeruli and tubules cells, pericytes and pigment epithelium cells of the retina, and Schwann cells. These features make CD36 an important component of the pathogenesis of DM and its complications, but also a promising target in the treatment of these disorders. The detrimental effects of CD36 signaling are mediated by the uptake of fatty acids and modified lipoproteins, deposition of lipids and their lipotoxicity, alterations in insulin response and the utilization of energy substrates, oxidative stress, inflammation, apoptosis, and fibrosis leading to the progressive, often irreversible organ dysfunction. This review summarizes the extensive knowledge of the contribution of CD36 to DM and its complications, including nephropathy, retinopathy, peripheral neuropathy, and cardiomyopathy.
Highlights
Widespread research aimed to thoroughly understand the cluster of differentiation 36 (CD36)has been carried out for the last 40 years
T2DM related to factors such as insulin resistance, high oxidized low-density lipoprotein (oxLDL), systemic low-grade inflammation, or hepatosteatosis, stimulates CD36 expression in monocytes and macrophages localized in adipose tissue, the liver, and arteries leading to elevated plasma soluble CD36 (sCD36)
Excessive plasma free fatty acids (FFAs), derived from lipolysis of adipose tissue or diet, may result in the intracellular influx of fatty acids (FAs) exceeding the capacity of cells for their utilization
Summary
Widespread research aimed to thoroughly understand the cluster of differentiation 36 (CD36). Has been carried out for the last 40 years At first, it was focused on the characteristics of the CD36 gene and protein, its tissue and subcellular localization, and its function, and at a later stage understanding the role of CD36 in the pathogenesis of many diseases. CD36 function is associated with the modulation of the inflammatory response and carbohydrate and lipid metabolism of these cells. This made CD36 a serious “candidate” for another protein involved in the pathogenesis of DM and its complications. Our considerations may form the basis for the development of further research and a new approach to treatment and new diagnostic or prognostic markers for DM and its complications
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
