Abstract
A study of 110 patients with membranoproliferative glomerulonephritis (MPGN) revealed that this disease appears in a simple form and in a lobular form. Both forms are characterized by a differently severe proliferation of mesangial cells and by a mostly extensiv thickening of the glomerular basement membrane. The proliferation of mesangial cells and thickening of the glomerular basement membrane is more severe in the lobular form of MPGN. Dense deposit lesions were observed in association with both the simple form and the lobular form of MGPN. An analysis of the morphological and clinical features of MPGN in patients with dense deposits in the glomerular capillary walls failed to indicate that dense deposits represent a unique disease entity.
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