Abstract

The molecular weight distributions of chondroitin sulphate from normal articular cartilage of the lower femoral epiphysis from human autopsy cases of different ages and from osteoarthritic cartilage have been determined by gel chromatography on Sephadex G-200. The polysaccharide samples fell within the same molecular weight range but differed with respect to molecular weight distribution. The average molecular weight of chondroitin sulphate from normal articular cartilage was higher in newborn and young individuals than in adults or the aged. Chondroitin sulphate from osteoarthritic cartilage had a lower molecular weight than that from macroscopically normal cartilage. The observed variations in polysaccharide chain length are discussed.

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