Abstract
ATP-sensitive potassium channels (KATP) in mitochondria are postulated to play a key role to protect mitochondria and myocytes from cardiac ischemic insult. The sulfonylurea receptor-2 (SUR2) is a subunit of KATP in sarcolemma, although its role in mitochondrial physiology is unclear. Mice where the SUR2 gene was disrupted (SUR2 mutant) have been shown to be constitutively protected from ischemic injury.
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