The Midterm Effect of Iliac Vein Stenting following Catheter-directed Thrombolysis for the Treatment of Deep Vein Thrombosis

Abstract

When following catheter-directed thrombolysis (CDT) for deep vein thrombosis (DVT), the stenosed iliac veins is controversy. To evaluate the mid-term outcomes of CDT with or without stent implantation for DVT in the presence of iliac vein compression. Seventy-three patients with iliac vein compression following CDT for acute lower extremity DVT from January 2009 to December 2014 were retrospectively analyzed. There were 32 males and 41 females, with average age of 53.57±15.60years (median: 45years, range: 20-79years). After CDT, patients with iliac vein compression were divided into 2 groups: the stenting group (n=40) and the nonstenting group (n=33). Patency rate of the deep vein, chronic change of vessels, clinical, etiological, anatomical, and pathological elements (CEAP) classification, venous clinical severity score, and Villalta scale were chosen to evaluate the midterm and long-term outcomes. Eighty-eight limbs among the patients (58 unilateral and 15 bilateral) were followed with mean time of 38.38±14.91months. The difference in vein patency between 2 groups (85.17±25.62 vs. 54.61±40.42) was statistically significant (P<0.05). According to the C in CEAP classification, the difference in clinical manifestations between the 2 groups was statistically significant (P<0.05). In addition, the Villalta scale scores were also significantly different between the 2 groups (1.73±2.86 vs. 4.39±5.16, P<0.05). Stent implantation in severely stenosed iliac segments following CDT for lower extremity DVT increased the patency of deep veins and improved midterm quality of life compared with that of nonstenting.