Abstract
4'Chloro-4-biphenylol, the major metabolite of 4-chlorobiphenyl in the rat, was given intraperitoneally to rats, and the urine and feces were examined for possible metabolic degradation products. The structure of the major urinary metabolite was elucidated by mass and nuclear magnetic resonance spectroscopy and shown to be 4'-chloro-3,4-biphenyldiol. Two chloromethoxbiphenylols (m-4) were also identified in the urine extracts but they could not be separated by chromatographic procedures. Demethylation of the mixture gave 4'-chloro-3,4-biphenyldiol as the sole product, thus indicating that the two components of the mixture were 4'-chloro-3-methoxy-4-biphenylol and 4'-chloro-4-methoxy-3-biphenyldiol. No 4'-chloro-4-biphenylol metabolites were isolated in the fecal extracts, and mass spectrometric analysis of the crude urine and feces extracts did not reveal any chlorine-containing degradation products that could be derived by oxidative fission of the biphenyl nucleus.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
