The Metabolism of 36 Cl-Clopidol (3,5-Dichloro-2,6-Dimethyl-4-Pyridinol) in Chickens

Abstract

INTRODUCTIONCLOPIDOL (3,5-dichloro-2,6-dimethyl-4-pyridinol) is a new anti-coccidial compound which is being used for the control of coccidiosis in chickens (Stevenson, 1965; Stock et al., 1967). As part of the biochemical studies on this compound a series of investigations on the distribution and fate of the compound within the chicken were undertaken using 36 Cl-clopidol.In an initial study on the distribution of the compound in chicken tissues (Bauriedel, 1964) it was observed that a radioactive compound or compounds were present in the various tissues when the bird was fed a feed containing 0.0125% of the 36 Cl-clopidol.If the radioactivity was calculated in terms of the original compound fed to the bird, the muscle tissue contained approximately 3 to 4 p.p.m. of the compound while the liver tissue contained from 10 to 12 p.p.m. of the compound.When the treated feed was withdrawn from the birds, there was a rapid decrease in…