Abstract
BackgroundSeveral traditional medicines have been developed among communities as part of the efforts to improve thrombocytopenia in patients with Dengue virus infection (DVI). Among those efforts is the administration of Monascus jmbA rice (MJR), which is rice fermented with Monascus purpureus. The administration of MJR is believed to increase the platelet count in patients with DVI.AimThe objective of this study is to elucidate the mechanism of the effects of MJR on increased levels of platelets in DVI serotype 3 through changes in IL-3, IL-6, IL-11 and TNF-α.MethodsIt was a true experimental laboratory study using the randomized posttest only control group design. The study compared between groups of wistar rats were being treated only with group IVD wistar rats who experienced treatment followed by administration of MJR as well as groups of wistar rats without any treatment as a control group.ResultsThe increase in platelet count in the group treated with DVI + MJR was higher than that treated with only DVI and the difference was a significant (P<0.05). Increased levels of TNF-α in the group treated with DVI + MJR were lower than that treated with only DVI and the difference was significant (P<0.05). The significant levels of the causal relationship of TNF-α with IL-6, TNF-α with IL-11 and IL- 6 with platelets were 0.044 (P<0.05), 0.029 (P<0.05) and 0.041 (P<0.05), respectively.ConclusionMJR is capable of increasing platelet count through the role of TNF- α and IL-6 in Wistar rats infected with DVI serotype 3.
Highlights
Several traditional medi- DVI so that the management remains more the study was the white rats (Rattus norvegicines have been developed among communities as part of the efforts to improve thrombocytopenia in patients with Dengue virus infection (DVI)
The mean increase in platelet count for the group treated with DVI and Monascus jmbA rice (MJR) was higher than for the group treated with only DVI and a significant difference was found at P
The mean increase in the levels of IL-3 for the group treated with DVI and MJR was lower than for the group treated with only DVI but significant difference was not found at P> 0.05; this study did not demonstrate that administration of MJR had an effect on increased platelet count through changes in the levels of IL-3 in Wistar rats infected with Dengue virus serotype 3
Summary
Several traditional medi- DVI so that the management remains more the study was the white rats (Rattus norvegicines have been developed among communities as part of the efforts to improve thrombocytopenia in patients with Dengue virus infection (DVI). Among those efforts ly is the administration of Monascus jmbA rice (MJR), which is rice fermented with n Monascus purpureus. The administration of o MJR is believed to increase the platelet count in patients with DVI. E Aim: The objective of this study is to s elucidate the mechanism of the effects of u MJR on increased levels of platelets in DVI l serotype 3 through changes in IL-3, IL-6, ia IL-11 and TNF-α
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