Abstract
The evidence in support of the postulation of three major sites of binding of acetyl and two of malonyl groups to the pigeon liver fatty acid synthetase is critically reviewed. Analyses of the chemical properties of these sites, when free and when esterified with acetyl or malonyl groups, and analyses for the amino acids present in the peptides containing these sites, has led to their identification as the SH groups of 4′-phosphopantetheine and cysteine and the hydroxyl group of a hydroxyamino acid. The enzymatic synthesis of other enzyme-bound intermediates of fatty acid synthesis has also been effected, and the sites of binding of each intermediate to the protein has been determined. From data on the sites of binding of intermediates to the fatty acid synthetase and the order of transfer from one site to another a mechanism of fatty acid synthesis is postulated.
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