Abstract
“Electron-affinic” radiosensitizers generally mimic oxygen in modifying cellular radiosensitivity, although not necessarily by the same molecular mechanisms. Useful mechanistic probes include quantitative relationships between chemical properties and efficacy, although the latter can usually be expressed only in terms of extracellular concentrations. The response vs concentration curves can also provide a test of a mechanistic model. Some possible mechanisms of radiosensitization are outlined: sensitization of damage from direct energy absorption; oxidation of radicals on the sugar/phosphate backbone of DNA; oxidation of base radicals; and radiation-induced binding of radiosensitizers. Each model is approached from the viewpoint of the known redox relationships with radiosensitizers and competition with thiols which serve to reduce the effect.
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Schedule a callMore From: International Journal of Radiation Applications and Instrumentation. Part C. Radiation Physics and Chemistry
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