Abstract
The paper deals with the study of the mechanism of antipyrogenic action exerted by cortisone in dinitrophenol hyperthermia. The author proceeded from the fact that dinitrophenol hyperthermia is connected with a considerable intensification of the oxidative processes in the tissues, while the activity of the thermoregulating centers is directed towards discharge of heat from the body. If cortisone depresses the condition of these centers, hyperthermia would be more pronounced against the background of its action. However, cortison administration in a dose of 25 mg leads to the reduction of the hyperthermia intensity in rabbits in comparison with controls. Since the action of dinitrophenol is intensified by thyrotoxin, whereas cortisone reduces the production of the latter, experiments were staged on thyroidectomized rabbits. Hyperthermia was intensified in these animals by cortisone administration. Hence the antipyrogenic effect of cortisone tends to remove its depressing effect on the thermoregulating centers.
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