Abstract
Recently, a large number of studies focus on (i) adipose tissue endocrine and paracrine function, and (ii) adipose-immune interactions herein referred to as adipoimmunology. In effect, a wide range of signaling proteins, dubbed adipokines, was identified as endocrine and paracrine secretory products of adipocytes and associated stromal vascular cells, including macrophages, lymphocytes and mast cells, the latter being less evaluated as compare to the formers. During obesity immune cells migrate into adipose tissue and inflame it by the secretion of a large amount of adipokines and thus trigger the development of so-called low grade inflammation-related diseases. Based on Steve Galli`s concept of mast cell as master cells in many biological and pathological processes (New Engl J Meet 1993; 328:257-265), here we highlight recent studies on the significance of adipose mast cells in the pathogenesis and therapy of cardiometabolic diseases (atherosclerosis, obesity, type 2 diabetes mellitus, metabolic syndrome) and breast cancer. Knowledge of the master work of these cells may provide a background for mast cell-targeted pharmacology for low grade inflammation-related diseases. Adipobiology 2015; 7: 15-19 Key words : adipose tissue, adipokines, atherosclerosis, breast cancer, inflammation, mast cells, obesity
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