Abstract
This study was designed to explore the relationship between anorexia nervosa and depression and to evaluate the role that endocrine hormones play in anorexia nervosa with functional hypothalamic amenorrhea and comorbid depression. In this study, thyroid hormones and sex hormones were compared between 30 first-episode drug-naive female patients with anorexia nervosa with depression (AND), and 20 female patients with anorexia nervosa with no depression (ANND). There were no differences between anorexia nervosa participants with and without depression in thyroid hormones levels. Patients with AND had significantly lower prolactin serum levels; patients with AND had a median [P25, P75] prolactin level of 213.0 uIU/ml [12.1-268.2] vs. 446.6 uIU/ml [119.1-35.5] for patients with ANND. There were no differences in other sex hormones between the two groups. Our data suggested that a lower prolactin serum level is a characteristic of first-episode neuroleptic-naive patients with AND.
Highlights
Anorexia nervosa (AN) is a potentially life-threatening disorder typically seen in adolescent girls (Stergioti et al, 2013)
This study was designed to explore the relationship between anorexia nervosa and depression and to evaluate the role that endocrine hormones play in anorexia nervosa with functional hypothalamic amenorrhea and comorbid depression
There were no differences between anorexia nervosa participants with and without depression in thyroid hormones levels
Summary
Anorexia nervosa (AN) is a potentially life-threatening disorder typically seen in adolescent girls (Stergioti et al, 2013). AN is associated with a lifelong trajectory and the continued appearance of multiple risk factors over the entire disease time course (Gicquel, 2013). Adolescents with functional hypothalamic amenorrhea show a higher incidence of subclinical symptoms of AN, including psychosomatic discomfort, and mild depressive traits (Bomba et al, 2007). Functional hypothalamic amenorrhea might represent part of the AN biological spectrum, and a link between these two conditions might exist, possibly related to the degree of psychological and/or hormonal dysfunction (Bomba et al, 2014). With the exception of the reports, four risk factors including young age, low body mass index (BMI), the pure restrictive form of the disease, and male sex were observed
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