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The long roots of ibogaine: A journey from plant to pharmaceutical

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This study reviews the complex colonial, cultural, and scientific history of ibogaine prior to the 1960s, highlighting its early use, indigenous knowledge, and multiple commercial formulations, and challenges simplified narratives by emphasizing its international, multifaceted development and the role of Congo Basin communities.

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Abstract Background and aims Ibogaine, one of the oldest psychedelic alkaloids introduced to Western society and medicine, has a largely overlooked history prior to Howard Lotsof's accidental identification of its anti-addictive properties in the 1960s. This manuscript explores some previously hidden aspects of ibogaine, with a focus on the entangled cultural, colonial, and scientific histories related to its early development from plant and ritual remedy to commercialized pharmaceutical before the 1960s. Methods The article is primarily based on a non-systematic literature review of various discoveries found in historical sources. In structuring the findings, we outline three main and somewhat overlapping phases of ibogaine's historical trajectory before the 1960s: i) the colonial appropriation and classification of ibogaine-containing plants from the Congo Basin during French colonial rule, ii) the isolation of ibogaine from the Tabernanthe iboga plant in 1900 and the early pharmaceutical research on its effects and uses, mainly in the French scientific community, and iii) the commodification of ibogaine in several pharmaceutical products and their international diffusion throughout the 20th century. Drawing on a historiographical approach rooted in postcolonial perspectives on colonial botany, biopiracy, and the intellectual property system, our analysis foregrounds the power-relations that have structured each of these three phases of ibogaine's early development, use, and commercialization as a pharmaceutical. Results Throughout this historical investigation, we present evidence that ibogaine was commercialized in several retail medicines beyond the well-known Lambarène . These included Dragées Nyrdahl, Grains des Anémiques, Syséros, Viris Lucet , Ibobiose , and Iperton . We further present discounted records documenting local uses of iboga in the Congo Basin, alongside early scientific publications on ibogaine, both of which served to guide and contextualize the medical research conducted during the early and mid-20th century. These findings complicate simplified narratives of the drug discovery of ibogaine, underscoring the critical role of indigenous medicinal knowledge in contributing to and shaping subsequent scientific understanding. Moreover, we identify evidence that ibogaine was first used in Mexico in 1913 for the treatment of a substance use disorder – a finding that challenges established historiographies and compels a revision of the dominant account of the ‘discovery’ of ibogaine's anti-addictive potential. Conclusions The article uncovers a range of previously overlooked historical sources that broadens the understanding of ibogaine's international trajectory and its embeddedness in various cultural, colonial, and scientific contexts. By illuminating ibogaine's multifaceted past, we seek to deepen the understanding of its contemporary framing and contextualize its potential future use in Western medicine. This historical inquiry contributes to a more nuanced and comprehensive account of ibogaine's past and its evolving place at the intersection of pharmacological and cultural histories and changing power dynamics. Among other things, we complicate unilinear accounts of who ‘discovered’ the anti-addictive effects of ibogaine, and we provide historical grounds for recognizing the people of the Congo Basin as both knowledge and resource providers of ibogaine's early development and commercialization as a pharmaceutical.

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  • Arizona Journal of Hispanic Cultural Studies
  • Joseba Gabilondo

Historical Memory, Neoliberal Spain, and the Latin American Postcolonial Ghost: On the Politics of Recognition, Apology, and Reparation in Contemporary Spanish Historiography Joseba Gabihndo has taught at several universities: Duke University, BrynMawr University , SUNY Stony Brook and University of Florida. Currently he is an Assistant Professor at the Center for Basque Studies, University of Nevada, Reno. He has published several articbs on Hollywood cinema and blockbusters in the context ofghbal culture, Spanish nationalism , postnationalism, masculinity , and queer theory. He hasjustfinishedan essay collection on contemporary Spanish-, American- and French-Basque literature entitledNazioaten hondarrak (The Remnants of the Nation ). He is currently working to finish α cultural and postnational history of Basque literatures from the Renaissance to the twentyfirst century entitbd Before Babel. Historical Memory, European Fundamentalism, and Colonial Ghosts To paraphrase the opening of the Communist Manifesto, a [new] specter is haunting Europe —the specter oÃ- fundamentalism.1 These days the term "fundamentalism" is mostly applied to different forms of resistance to the West, i.e. Muslim fundamentalism. My use of fundamentalism refers to something quite different: legitimations of the West. More specifically, I use "fundamentalism" to refer to the neoliberal turn taken by many European (and American) states which re-imagine themselves in a neonationalist/imperialist fashion. They do so by forgetting their colonial past while turning their internal others into the only racist and fundamentalist subjects . Le Pen's ultra-right politics in France or the welldocumented case of xenophobia surrounding El Ejido in Spain are two clear examples of the kind of ideological processes to which I refer. In this respect I equate fundamentalism with neoliberalism here.2 I will focus on contemporary Spanish historiographical discourse and its central role in articulating this neoliberal, fundamentalist ideology. But before focusing on Spain, I would like to cite several French and German scandals in order to expose the general European scope of this fundamentalist ideology. I have chosen the public form of the "scandal," because a "scanArizona Journal of Hispanic Cultural Studies Volume 7, 2003 248 Arizona Journal of Hispanic Cultural Studies dal" captures the emerging yet non-hegemonic status of any new ideology—a status that the very nature of the scandal reveals and conceals at the same time. The scandal reflects an abject event or discourse that the majority of the population desires but cannot embrace or rejects but cannot renounce. These scandals are ultimately about the past and its memory. They point to the emergence of a new ideology endowed with a very specific historical imagination: a neoliberal, fundamentalist memory. In November of 2002, Valéry Giscard d'Estaing, the ex-president of the French Republic and head of the Convention for the Future of the European Union, gave an interview to Le Monde and made several remarks about the rejection of Turkey's application to the EU. He noted that Turkey does not belong in the European Union; in his own words, "it would represent the end of Europe" (Le Monde, my translation). D'Estaing said that Turkey's "capital is not in Europe, 95% of its population is outside Europe; it is not a European country" (Schweizerische , my translation). He concluded that admitting Turkey, an official candidate since 1999, would open the European gates for other North African states: "you will have a Moroccan request (for EU membership), the King of Morocco said it long time ago" (Schweizerische, my translation). One would have to wonder whether French colonial rule in Africa in the nineteenth and twentieth centuries was European , and rhus, whether the postcolonial effects of France's imperialism are European as well. Ultimately one could interpret d'Estaign's remarks to mean that French postcolonial subjects are no longer European let alone French, even if they live in France or are French citizens. D'Estaign's latest remarks echo those he made in 1990: "Immigration must be totally stopped" (Huntington 201). D'Estaign's declarations attest to more generalized European fears towards the uncanny postcolonial return of the colonial subject which is now transformed into the global harbinger of European demise. His remarks show that Le Pen is not an island phenomena and that we are dealing with a larger ideological problem. Very correctly, the...

  • Research Article
  • 10.26565/2226-0994-2024-70-5
ON THE HISTORICAL DISCRETENESS OF THE FUNCTION OF LANGUAGE AND AUTHORSHIP IN THE CONTEXT OF MICHEL FOUCAULT’S “THE ORDER OF THINGS”
  • Jun 21, 2024
  • The Journal of V. N. Karazin Kharkiv National University, Series "Philosophy. Philosophical Peripeteias"
  • Oleksandr Loiko

The article analyzes forms of authorship that were characteristic of Western culture at specific periods and emerged or disappeared in connection with the emergence or disappearance of the corresponding function of language. The analysis was carried out based on the materials and methodology proposed by Michel Foucault in his fundamental work "The Order of Things," involving the works of other researchers. It is noted that the discreteness of the function of language in culture, as proven by Foucault, undermines not only the notion of the foundational function of the subject but also the notion of the invariance and universality of the author's function. Based on descriptions of the function of language within each of the three "epistemes," it is demonstrated that in different periods of the history of Western culture, "authorship" was understood as various cultural practices that are difficult to reduce to a single concept. In conclusion, three types of authorship that emerged in Western culture during different historical periods were identified, named, and described: "Author-Augur" (late antiquity – mid-17th century), "Author-Creator" (mid-17th century – early 19th century), and "Author-Medium" (early 19th century – 20th century). The article argues that the "death of the author," in the context of "The Order of Things," is a consequence of the decline of the "classical episteme" – conditions of the possibility of knowledge in which "representation" was the only locus of the world's existence, and under the Cartesian "cogito ergo sum," according to Foucault, what was actually implied was: "I think, therefore the world exists." After it was revealed within the "modern episteme" that the being of man is outside the being of language, the classical Creator was replaced by the Medium. The text separately explains how the proposed concept of the "Medium" fundamentally differs from the "Scripter" (Roland Barthes) and from the so-called "Simple Performer of Pure Ritual" (Michel Foucault).

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